Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone
نویسندگان
چکیده
منابع مشابه
Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone.
We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of unchanged dexamethasone plasma levels. Bet...
متن کاملDexamethasone Supression Test in Depressives Treated with Ect
A cohort of endogenous depressives and normal controls were studied to examine the role of DST in depressives treated with ECT. Weekly DST estimation was done and depression was assessed on HRS-D. 73.6% patients were found to be non suppressors as compared to controls in whom 16.7% were non suppressors. 60% DST positive patients showed clinical improvement while 50% DST negative did not show im...
متن کاملCharacterization of Glucocorticoid Binding Capacity in Human Mononuclear Lymphocytes: Increase by Metyrapone is Prevented by Dexamethasone Pretreatment.
Abstract Autoregulation of receptor systems by their own ligands is a well established biological phenomenon. While down-regulation of the glucocorticoid binding capacity by glucocorticoids has been shown in animals and humans, data on up-regulation processes in humans are lacking. To further explore glucocorticoid receptor plasticity in relation to endogenous ligands, glucocorticoid binding pa...
متن کاملCalmodulin antagonists competitively inhibit dexamethasone binding to the glucocorticoid receptor.
Steroid hormones exert their glucocorticoid activity by binding reversibly to a receptor protein in the cytoplasm of target cells [ 1,2]. We have shown [3] that Ca2+ inhibit the rate of association of dexamethasone, a semi-synthetic glucocorticoid, with the glucocorticoid receptor. The half-maximum effect was seen at 0.3 PM free Ca2+, a concentration within the range (0. l1 PM) of fluctuations ...
متن کاملEndothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity
We have previously shown that in vitro sensitivity to dexamethasone (DEX) stimulation in human endothelial cells is positively regulated by the glucocorticoid receptor (NR3C1, GR). The present study determined the role of differential GR transcriptional regulation in glucocorticoid sensitivity. We studied 25 human umbilical vein endothelial cells (HUVECs) that had been previously characterized ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 1991
ISSN: 0006-3223
DOI: 10.1016/0006-3223(91)90252-h